Transcription Machinery

TFIID

TFIIA, IIB, IIE

IIF, IIH

The major research interest of the Wang lab is the regulation of gene transcription and its role in cell proliferation and human disease. Our studies focus on the function of the transcription factor complex TFIID and how mutations in its TAF subunits contribute to cancer or neuronal developmental and degenerative disorders. The Wang lab uses molecular and structural biology as well as biochemical approaches to 1) investigate the normal function of the largest TFIID subunit TAF1 in gene transcription, 2) characterize debilitating mutations in TAF1 that may contribute to cancer or cognitive impairment and 3) assess the potential of TFIID subunits as drug targets or diagnostic markers for human disease. Our long-term goal is to understand how dysregulation of gene transcription promotes disease and to use this information to identify new diagnostic and therapeutic approaches to improve human health.